Molecular Characterization of Cat Factor XII Gene and Identification of a Mutation Causing Factor XII Deficiency in a Domestic Shorthair Cat Colony
نویسندگان
چکیده
منابع مشابه
A novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency
The feline F12 gene was examined to identify a mutation associated with coagulation factor XII (FXII) deficiency in a litter of 6 cats, including 2 cats with severely reduced FXII activity (7.1 and 9.3%, respectively) and 4 cats with moderately reduced FXII activity (range 36.0 to 46.3%). Cats with severely reduced FXII activity were homozygous for a G to C missense mutation in exon 13 of the F...
متن کاملCharacterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris. In the patient's plasma, factor XII activity and antigen levels were only 1.6% and 5.0%, respectively, of those seen in a normal subject. Immunoblot analysis showed that the secreted factor XII Tenri existed not only as a monomer (76 kD...
متن کاملFactor XII Deficiency
Factor XII ia a single-chain beta-globulin serine protease with a molecular weight of 80,000 84,000 daltons and a plasma concentration of approximately 30 pg/mL. Proteolytic cleavage of factor XII is mediated by charged surfaces (glass, kaolin, cellite, dextran sulfate, endotoxin, urates, crude collagen, sulfatides), autoactivation, and kallikrein. Prekallikrein, factor XI, factor VII, plasmino...
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CASE SUMMARY This report describes the clinical and parasitological findings in a domestic shorthair cat with isolated thoracic tetrathyridiosis. The cat was a stray from Malta that had lived in Germany for several years since as an indoor-only cat. Therefore, the process of infection remains very unusual. In this case it must be considered that the cat had been infected years previously while ...
متن کاملA Case Report of Second Stage Digital Fibrosarcoma in a 3 Years Old Domestic Shorthair Cat
Objective: Sarcomas are neoplasms of mesenchymal (stem cell) origin and are rare skin diseases of cats and may occur anywhere on the cat body.The main etiologies of soft tissue sarcomas are Feline sarcoma virus induced sarcomas, vaccine site sarcomas, trauma, inflammation and radiation. Methods: In March 2014, a three years old male domestic shorthair cat were referred to a private veterinary c...
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ژورنال
عنوان ژورنال: Veterinary Pathology
سال: 2014
ISSN: 0300-9858,1544-2217
DOI: 10.1177/0300985814532821